The Pittsburgh Pirates (15-30) square off against the Houston Astros (23-21). The matchup at PNC Park starts at 6:40 p.m. ET on Tuesday, June 3.

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5/17/2025 at Phillies: 6:05 p.m. ET. Starters - PIT: Carmen Mlodzinski, PHI: Zack Wheeler
5/18/2025 at Phillies: 1:35 p.m. ET. Starters - PIT: Paul Skenes, PHI: Mick Abel
5/19/2025 vs. Reds: 6:40 p.m. ET. Starters - PIT: Mitch Keller, CIN: Nick Lodolo
5/20/2025 vs. Reds: 6:40 p.m. ET. Starters - PIT: Bailey Falter, CIN: Nicholas Martínez
5/21/2025 vs. Reds: 12:35 p.m. ET. Starters - PIT: Andrew Heaney, CIN: Brady Singer
5/22/2025 vs. Brewers: 6:40 p.m. ET. Starters - PIT: Carmen Mlodzinski, MIL: Tobias Myers
5/23/2025 vs. Brewers: 6:40 p.m. ET. Starters - PIT: Paul Skenes, MIL: Freddy Peralta
5/24/2025 vs. Brewers: 4:05 p.m. ET. Both starters TBA
5/25/2025 vs. Brewers: 1:35 p.m. ET. Both starters TBA
5/26/2025 at Diamondbacks: 8:10 p.m. ET. Both starters TBA
5/27/2025 at Diamondbacks: 9:40 p.m. ET. Both starters TBA
5/28/2025 at Diamondbacks: 3:40 p.m. ET. Both starters TBA
5/30/2025 at Padres: 9:40 p.m. ET. Both starters TBA
5/31/2025 at Padres: 9:40 p.m. ET. Both starters TBA
6/1/2025 at Padres: 5:10 p.m. ET. Both starters TBA
6/3/2025 vs. Astros: 6:40 p.m. ET. Both starters TBA
6/4/2025 vs. Astros: 6:40 p.m. ET. Both starters TBA
6/5/2025 vs. Astros: 6:40 p.m. ET. Both starters TBA
6/6/2025 vs. Phillies: 6:40 p.m. ET. Both starters TBA
6/7/2025 vs. Phillies: 4:05 p.m. ET. Both starters TBA

5/17/2025 at Rangers: 7:05 p.m. ET. Starters - HOU: Ronel Blanco, TEX: Tyler Mahle
5/18/2025 at Rangers: 1:05 p.m. ET. Starters - HOU: Ryan Gusto, TEX: Jack Leiter
5/19/2025 at Rays: 7:05 p.m. ET. Starters - HOU: Framber Valdez, TB: Ryan Pepiot
5/20/2025 at Rays: 7:05 p.m. ET. Starters - HOU: Colton Gordon, TB: Zack Littell
5/21/2025 at Rays: 1:10 p.m. ET. Starters - HOU: Hunter Brown, TB: Taj Bradley
5/22/2025 vs. Mariners: 8:10 p.m. ET. Starters - HOU: Lance McCullers, SEA: Emerson Hancock
5/23/2025 vs. Mariners: 8:10 p.m. ET. Starters - HOU: Ronel Blanco, SEA: Bryan Woo
5/24/2025 vs. Mariners: 4:10 p.m. ET. Both starters TBA
5/25/2025 vs. Mariners: 2:10 p.m. ET. Both starters TBA
5/27/2025 vs. Athletics: 8:10 p.m. ET. Both starters TBA
5/28/2025 vs. Athletics: 2:10 p.m. ET. Both starters TBA
5/29/2025 vs. Rays: 8:10 p.m. ET. Both starters TBA
5/30/2025 vs. Rays: 8:10 p.m. ET. Both starters TBA
5/31/2025 vs. Rays: 4:10 p.m. ET. Both starters TBA
6/1/2025 vs. Rays: 2:10 p.m. ET. Both starters TBA
6/3/2025 at Pirates: 6:40 p.m. ET. Both starters TBA
6/4/2025 at Pirates: 6:40 p.m. ET. Both starters TBA
6/5/2025 at Pirates: 6:40 p.m. ET. Both starters TBA
6/6/2025 at Guardians: 7:10 p.m. ET. Both starters TBA
6/7/2025 at Guardians: 4:10 p.m. ET. Both starters TBA

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