The Astros scattered seven hits Tuesday night but could not push across a run as they lost to the White Sox, 2-0.
Framber Valdez got the loss and is now 5-5 on the season.
Alex Bregman and Trey Cabbage both had two hits.
The series continues tonight in Chicago with a 7:10pm first pitch. The On Deck Show starts at 6pm on SportsTalk790.