Texans veteran running back David Johnson has been placed on the reserve-COVID-19 list and is out for Sunday's game against the Seattle Seahawks.
Johnson missed last week's game against the Indianapolis Colts due to illness and a leg injury.
Practice squad running back Jaylon Samuels was placed on the practice squad-COVID-19 list Saturday.
Johnson has rushed for 176 yards and no touchdowns, averaging 3.1 yards per carry. He has 28 receptions for 214 yards and one touchdown
With Johnson out, the Texans will lean heavily on Rex Burkhead as the primary running back again. They will also have some carries for backup Royce Freeman.
Wide receiver Brandin Cooks, the Texans' leading pass-catcher, is active after being placed on the injury report Friday with a back injury and listed as questionable.
Tight end Jordan Akins is active for the first time since a road loss to the Miami Dolphins.
The Texans deactivated safety Terrence Brooks (hamstring), linebacker Kevin Pierre-Louis (hamstring, wrist), cornerback Jimmy Moreland (foot), wide receiver Chris Moore, center Cole Toner and quarterback Deshaun Watson (non-injury reasons-personal matter).