The Rockets are currently on a three-game losing streak following Tuesday's 115-102 loss to the Indiana Pacers.
Alperen Sengun scored 25 points, while Jalen Green recorded 12 points and five turnovers.
"We need more playmaking out of [Green]," head coach Ime Udoka said.
The loss to the Pacers was the second of a back-to-back as the Oklahoma City Thunder defeated the Rockets 137-128 on Monday. Houston was without Sengun, Amen Thompson, Dillon Brooks, Fred VanVleet and Tari Eason in that contest.
"All these back-to-backs have added up," Udoka said.
The Rockets have the most games by a team on no rest this season, with 15 games.
"Until you prove yourself in the league, you'll get a favorable schedule eventually."
The Rockets will look to get back into the win column when they face the Pelicans in New Orleans on Thursday.