Texans starting running back Rex Burkhead went to the locker room with a groin injury.
The Texans' leading rusher with 40 yards on 11 carries Sunday against the Seattle Seahawks, the former New England Patriots backup is questionable to return.
The Texans have the lowest-ranked running game in the NFL, and Burkhead has been starting with David Johnson sidelined again on the reserve-COVID-19 list.
They've rushed for just 48 yards on 20 carries against the Seahawks.
Without Burkhead, the Texans' only running back on the active roster is Royce Freeman, who has three yards on seven carries